Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway.

@article{Li2016OverexpressionOL,
  title={Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway.},
  author={Xuechao Li and Tao Li and De-qiang Chen and Peng Zhang and Yarong Song and Hongxue Zhu and Yajun Xiao and Yifei Xing},
  journal={Oncology reports},
  year={2016},
  volume={35 1},
  pages={
          584-92
        }
}
Lysine-specific demethylase 1 (LSD1) is the first defined histone demethylase, and was found to be closely correlated with the development and progression of various types of cancers, including prostate cancer (PCa). Previous research suggests that LSD1 is closely related with cell proliferation, angiogenesis, migration and invasion in PCa. However, it remains to be elucidated whether LSD1 is correlated with androgen-independent (AI) transition of PCa under androgen-ablated conditions. The… 

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