Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.

@article{Kathirvel2009OverexpressionOL,
  title={Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.},
  author={Elango Kathirvel and Kengathevy Morgan and Samuel William French and Timothy R. Morgan},
  journal={European journal of gastroenterology & hepatology},
  year={2009},
  volume={21 9},
  pages={973-83}
}
OBJECTIVE Cytochrome P4502E1 (CYP2E1) expression in the liver is increased in nonalcoholic fatty liver disease. The aim of this study was to determine whether CYP2E1 overexpression in the liver interferes with insulin signaling pathways in a mouse model of nonalcoholic fatty liver disease. METHODS Male mice containing the human CYP2E1 transgene under control of the mouse albumin enhancer-promoter (Tg) and control, nontransgenic mice were fed a diet containing 20% calories from fat for 8… CONTINUE READING
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