Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases.

@article{Barbier2003OverexpressionOL,
  title={Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases.},
  author={Maryse Barbier and Hubert Vidal and Pierre Desreumaux and Laurent Dubuquoy and A Bourreille and Jean-François Colombel and Christine Cherbut and J. -P. Galmiche},
  journal={Gastroenterologie clinique et biologique},
  year={2003},
  volume={27 11},
  pages={987-91}
}
BACKGROUND Leptin, a protein with a cytokine-like structure, is produced predominantly by adipocytes. It appears to play a key role in immune responses by increasing the secretion of Th1 and pro-inflammatory cytokines. As fat-wrapping is a characteristic feature of Crohn's disease (CD), and as increased leptin levels have been reported in animal models of intestinal inflammation, this study investigated whether mesenteric adipose tissue could be a source of leptin in human inflammatory bowel… CONTINUE READING

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