Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

@article{Hoeg1996OverexpressionOL,
  title={Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.},
  author={J M Hoeg and Silvia Santamarina-Fojo and Annie M. B{\'e}rard and J F Cornhill and Edward E. Herderick and S H Feldman and Christian C. Haudenschild and Boris L Vaisman and R F Hoyt and S J Demosky and Richard D. Kauffman and C M Hazel and Santica M. Marcovina and H B Brewer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 21},
  pages={11448-53}
}
  • J M Hoeg, Silvia Santamarina-Fojo, +11 authors H B Brewer
  • Published 1996 in
    Proceedings of the National Academy of Sciences…
Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity that nontransgenic control rabbits. This degree of overexpression was associated with a 6.7-fold increase in the plasma HDL cholesterol concentration in LCAT transgenic rabbits. On a 0.3% cholesterol diet, the HDL cholesterol concentrations increased from 24 +/- 1 to 39 +/- 3 mg/dl… CONTINUE READING
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