Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling.

@article{Kirchhefer2006OverexpressionOJ,
  title={Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling.},
  author={Uwe Kirchhefer and Gabriela Hanske and Larry R. Jones and Isabel Justus and Lars Kaestner and Peter Lipp and W. Schmitz and Joachim Neumann},
  journal={Cell calcium},
  year={2006},
  volume={39 2},
  pages={131-42}
}
In cardiac muscle, junctin forms a quaternary protein complex with the ryanodine receptor (RyR), calsequestrin, and triadin 1 at the luminal face of the junctional sarcoplasmic reticulum (jSR). By binding directly the RyR and calsequestrin, junctin may mediate the Ca(2+)-dependent regulatory interactions between both proteins. To gain more insight into the underlying mechanisms of impaired contractile relaxation in transgenic mice with cardiac-specific overexpression of junctin (TG), we studied… CONTINUE READING