Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-κB signaling.

@article{Yan2014OverexpressionOI,
  title={Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-κB signaling.},
  author={Zhaopeng Yan and Hongzhuan Yin and Rui Wang and Di Wu and Wei Sun and Baolin Liu and Qi Su},
  journal={Acta histochemica},
  year={2014},
  volume={116 3},
  pages={527-33}
}
Integrin-linked kinase (ILK), a ubiquitously expressed and evolutionally conserved serine/threonine kinase, has been shown to be aberrantly overexpressed and activated in diversified types of human malignancies, including colorectal cancer (CRC). However, the potential role of ILK in cancer cell migration and invasion remains to be elucidated. In this study, we introduced the human ILK gene into a low ILK-expressing human CRC cell line SW480. Cell migration and invasion were evaluated by the… CONTINUE READING

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