Overexpression of hyaluronan in the tunica media promotes the development of atherosclerosis.

@article{Chai2005OverexpressionOH,
  title={Overexpression of hyaluronan in the tunica media promotes the development of atherosclerosis.},
  author={Song Chai and Qing Chai and Carl Christian Danielsen and Peter Hansen Hjorth and Jene R Nyengaard and Thomas Ledet and Yu Yamaguchi and Lars Melholt Rasmussen and L. D. Wogensen},
  journal={Circulation research},
  year={2005},
  volume={96 5},
  pages={583-91}
}
The arterial content of hyaluronan (HA) undergoes diffuse changes as part of the diabetic macroangiopathy. Because HA influences the phenotype of vascular cells in vitro such as proliferation, migration, and secretion, it is tempting to speculate that diabetes-induced hastened cardiovascular disease may be linked to the increased amount of HA. To explore the pathophysiological role of altered HA content in the arterial wall in vivo, we created transgenic (Tg) mice with HA overexpression in… CONTINUE READING