Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.

@article{Varghese2002OverexpressionOH,
  title={Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.},
  author={Robin Varghese and Anthony D Gagliardi and Peter E Bialek and Siu-Pok Yee and Graham Forsyth Wagner and Gabriel E. Dimattia},
  journal={Endocrinology},
  year={2002},
  volume={143 3},
  pages={
          868-76
        }
}
In mammals stanniocalcin (STC) is widely expressed, and in the kidney and gut it regulates serum calcium levels by promoting phosphate reabsorption. To shed further light on its functional significance in mammals we have created several lines of mice that express a human STC (hSTC) transgene. Three lines expressed the hSTC transgene, but only two lines exhibited high expression and contained circulating hSTC, and in these animals there was a reduction in postnatal growth (30-50%) that persisted… CONTINUE READING
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