Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.

@article{Tanaka2004OverexpressionOH,
  title={Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.},
  author={Masashi Tanaka and Golnaz K. Mokhtari and Raya D. Terry and Leora B Balsam and Keun-Ho Lee and Theodoros Kofidis and Philip S. Tsao and Robert Clayton Robbins},
  journal={Circulation},
  year={2004},
  volume={110 11 Suppl 1},
  pages={II200-6}
}
BACKGROUND Ischemia-reperfusion injury is an important risk factor for graft coronary artery disease (GCAD). We hypothesized that overexpression of SOD1 in donor hearts would suppress ischemia-reperfusion injury and thereby reduce GCAD. METHODS AND RESULTS In one series, donor hearts of C57BL/6 (H-2b) transgenic mice overexpressing human SOD1 or C57BL/6 wild-type mice were heterotopically transplanted into C57BL/6 recipients and procured after 4 hours of reperfusion (n=6 each). Superoxide… CONTINUE READING