Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis.

@article{Boisfer1999OverexpressionOH,
  title={Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis.},
  author={Elisabeth Boisfer and Gilles Lambert and V{\'e}ronique Atger and Nhu Q Tran and Dani{\`e}le Pastier and Claire Benetollo and J F Trottier and I Beaucamps and Michela Antonucci and M Laplaud and Sabine Griglio and Jean Chambaz and A D Kalopissis},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 17},
  pages={11564-72}
}
Two lines of transgenic mice, hAIItg-delta and hAIItg-lambda, expressing human apolipoprotein (apo)A-II at 2 and 4 times the normal concentration, respectively, displayed on standard chow postprandial chylomicronemia, large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) but greatly reduced high density lipoprotein (HDL). Hypertriglyceridemia may result from increased VLDL production, decreased VLDL catabolism, or both. Post-Triton VLDL production was… CONTINUE READING
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