Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet.

@article{Otabe2007OverexpressionOH,
  title={Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet.},
  author={Shuichi Otabe and Xiaohong Yuan and Tomoka Fukutani and Nobuhiko Wada and Toshihiko Hashinaga and Hitomi Nakayama and Naotoshi Hirota and Masayasu Kojima and Kentaro Yamada},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 1},
  pages={E210-8}
}
Adiponectin, a physiologically active polypeptide secreted by adipocytes, shows insulin-sensitizing, anti-inflammatory, and antiatherogenic properties in rodents and humans. To assess the effects of chronic hyperadiponectinemia on metabolic phenotypes, we established three lines of transgenic mice expressing human adiponectin in the liver. When maintained on a high-fat/high-sucrose diet, mice of two lines that had persistent hyperadiponectinemia exhibited significantly decreased weight gain… CONTINUE READING