Overexpression of human KCNA5 increases IK V and enhances apoptosis.

  title={Overexpression of human KCNA5 increases IK V and enhances apoptosis.},
  author={Elena E. Brevnova and Oleksandr Platoshyn and Shen Zhang and Jason X-J Yuan},
  journal={American journal of physiology. Cell physiology},
  volume={287 3},
Apoptotic cell shrinkage, an early hallmark of apoptosis, is regulated by K+ efflux and K+ channel activity. Inhibited apoptosis and downregulated K+ channels in pulmonary artery smooth muscle cells (PASMC) have been implicated in development of pulmonary vascular medial hypertrophy and pulmonary hypertension. The objective of this study was to test the… CONTINUE READING