Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis.

@article{Nagy2008OverexpressionOG,
  title={Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis.},
  author={Norbert Nagy and Gautam Malik and Arp{\'a}d T{\'o}saki and Ye-shih Ho and Nilanjana Maulik and Dipak Kumar Das},
  journal={Journal of molecular and cellular cardiology},
  year={2008},
  volume={44 2},
  pages={252-60}
}
Mitochondrial glutaredoxin-2 (Glrx2) has been recognized as an important redox regulator in mammalian organs including heart. To date no investigations have addressed the potential role of Glrx2 in cardiac disorders. The present study examined if myocardial overexpression of Glrx2 in the heart could rescue the cardiac cells from apoptosis and necrosis induced by ischemia and reperfusion. The human Glrx2 transgene was created by placing a full-length cDNA fragment encoding human mitochondrial… CONTINUE READING

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