Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.

@article{Legan2008OverexpressionOG,
  title={Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.},
  author={Susan K. Legan and Igor Rebrin and Robin J. Mockett and Svetlana N Radyuk and Vladimir I. Klichko and Rajindar S. Sohal and William C. Orr},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 47},
  pages={32492-9}
}
The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement of reductive capacity by overexpression of glucose-6-phosphate dehydrogenase (G6PD), a key enzyme for NADPH biosynthesis, could protect against oxidative stress and extend the life span of transgenic Drosophila melanogaster. Overexpression of G6PD was achieved by combining a UAS-G6PD responder transgene at one of four independent loci with… CONTINUE READING
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