Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio).

@article{Her2011OverexpressionOG,
  title={Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio).},
  author={Guor Mour Her and Chia-Chun Hsu and Joonkee Hong and Chi-Yu Lai and Meng-Chieh Hsu and Hsi-Wen Pang and Sheng-Kai Chan and Wan-Yu Pai},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1811 9},
  pages={536-48}
}
Gankyrin is a small ankyrin-repeat protein that previous research has confirmed to be overexpressed in hepatocellular carcinoma (HCC). Although relevant literature has reported on gankyrin functions in cellular proliferation and tumorigenesis, the exact role of gankyrin is poorly understood in animal model systems. This study analyzed hepatic lipid accumulation in gankyrin transgenic (GK) zebrafish. Bromodeoxyuridine (BrdU)-positive cells were predominantly increased in the liver bud of GK… CONTINUE READING

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