Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis

@inproceedings{Bartczak2017OverexpressionOF,
  title={Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis},
  author={Agata M. Bartczak and Jianhua Zhang and Oyedele Adeyi and Achiya Zvi Amir and David R. Grant and Reginald M. Gorczynski and Nazia Selzner and Andrzej J. Chruscinski and Gary A. Levy},
  booktitle={World journal of gastroenterology},
  year={2017}
}
AIM To determine the effect of overexpression of fibrinogen-like protein 2 (FGL2) on regulatory T cell (Treg) and effector T (Teff) cell function on T cell-induced colitis in Rag1-/- mice. METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/- mice. RESULTS In vitro, fgl2Tg… CONTINUE READING

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