Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

@article{Swinnen2002OverexpressionOF,
  title={Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer},
  author={Johannes V. Swinnen and Tania A. Roskams and Steven Joniau and Hein P. Van Poppel and Raymond Oyen and Luc V. Baert and Walter Heyns and Guido Verhoeven},
  journal={International Journal of Cancer},
  year={2002},
  volume={98}
}
The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using a highly sensitive immunohistochemical detection technique (Envision). In comparison to normal or benign, hyperplastic glandular structures, which were all negative for FAS staining, immunohistochemical signal was evident in 24/25 low grade prostatic epithelial neoplasia (PIN) lesions, in 26/26 high grade PIN… 
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TLDR
It is reported that in prostate cancer fatty acid synthase expression is up‐regulated at the mRNA level together with other enzymes of the same metabolic pathway, pointing to selective activation of the fatty acid synthesis pathway and suggesting a shift in the balance of lipogenic gene expression in a subgroup of prostate cancers.
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TLDR
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TLDR
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TLDR
OA-519 expression correlates with higher tumor grades, larger tumors, and possibly with advanced stage, and thus, it is potentially of prognostic value in prostate cancer.
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