Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

@article{Swinnen2002OverexpressionOF,
  title={Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer},
  author={Johannes V. Swinnen and Tania A. Roskams and Steven Joniau and Hein P. Van Poppel and Raymond Oyen and Luc V. Baert and Walter Heyns and Guido Verhoeven},
  journal={International Journal of Cancer},
  year={2002},
  volume={98}
}
The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using a highly sensitive immunohistochemical detection technique (Envision). In comparison to normal or benign, hyperplastic glandular structures, which were all negative for FAS staining, immunohistochemical signal was evident in 24/25 low grade prostatic epithelial neoplasia (PIN) lesions, in 26/26 high grade PIN… 
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361 Citations
Highly Influential Citations
11
Background Citations
132
Methods Citations
1
Results Citations
6

361 Citations

Expression of fatty acid synthase and E-cadherin markers in cancer of the prostate
TLDR
Increased FASN immunohistochemical expression and reduced E-cadherin expression are associated with increased aggressiveness of prostatic carcinoma and bad prognosis, suggesting combined detection of the expression of both markers may provide an essential predictor for prognosis of prostatics carcinoma.
High‐level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
TLDR
Data suggest that high‐level expression of FAS in prostate cancer tissues is linked to phosphorylation and nuclear accumulation of Akt, a key metabolic enzyme linked to the synthesis of membrane phospholipids in cancer cells.
Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness.
TLDR
expression of FAS and fatty acid synthesis support an essential functional aspect of retinoblastoma cells, perhaps cell growth or survival, and its inhibition could represent an alternative treatment strategy in advanced and resistant retinOBlastomas.
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis
TLDR
The increased FAS expression, in lesions parallel to their increased breast cancer risk, suggests further studies to develop new markers of high‐risk lesions and to prevent breast cancer.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Immunohistochemical Expression of Fatty acid Synthase, Ki-67 and p53 in Squamous Cell Carcinomas of the Larynx
TLDR
It is suggested that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
TLDR
It is suggested that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.
Increased fatty acid synthase expression in prostate biopsy cores predicts higher Gleason score in radical prostatectomy specimen
TLDR
Increased FAS expression in prostate biopsy cores could be a novel parameter for predicting higher GS in RP specimens, and the treatment strategy for patients with high FASexpression in prostateBiopsy cores should be carefully determined.
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TLDR
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