Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers.

@article{Alam2007OverexpressionOE,
  title={Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers.},
  author={Syed Mahfuzul Alam and Jiro Fujimoto and Israt Jahan and Eriko Sato and Teruhiko Tamaya},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2007},
  volume={18 3},
  pages={485-90}
}
BACKGROUND The ligand ephrinB2 and the corresponding receptor EphB4 contribute to tumor growth in various human tumors. This prompted us to study the expression and localization of ephrinB2 and EphB4 in uterine endometrial cancers to analyze the ephrinB2/EphB4 functions against clinical backgrounds. MATERIALS AND METHODS We carried out immunohistochemistry and real-time RT-PCR to determine the histoscores and messenger RNA (mRNA) levels of ephrinB2 and EphB4, respectively, in 68 uterine… CONTINUE READING
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