Overexpression of enzymes that repair endogenous damage to DNA.

@article{Frsina2000OverexpressionOE,
  title={Overexpression of enzymes that repair endogenous damage to DNA.},
  author={Guido Fr{\`o}sina},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 8},
  pages={2135-49}
}
A significant contribution to human mutagenesis and carcinogenesis may come from DNA damage of endogenous, rather than exogenous, origin. Efficient repair mechanisms have evolved to cope with this. The main repair pathway involved in repair of endogenous damage is DNA base excision repair. In addition, an important contribution is given by O6-alkylguanine DNA alkyltranferase, that repairs specifically the miscoding base O6-alkylguanine. In recent years, several attempts have been carried out to… CONTINUE READING

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