Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.

@article{Sasaki2013OverexpressionOE,
  title={Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.},
  author={Motoko Sasaki and Takashi Matsubara and Norihide Yoneda and Kazuhiro Nomoto and Koichi Tsuneyama and Yasunori Sato and Yasuni Nakanuma},
  journal={Histopathology},
  year={2013},
  volume={62 3},
  pages={
          446-57
        }
}
AIMS   Intraductal papillary neoplasm of the bile duct (IPNB) usually has a favourable prognosis, but occasionally is associated with invasive carcinoma. Overexpression of the polycomb group protein enhancer of zeste homolog 2 (EZH2) is involved in the progression of malignant tumours. In this study, we examined the significance of EZH2 expression in IPNB and its association with clinicopathological features and the expression of p16(INK4a) , p53 and mucin core proteins. METHODS AND RESULTS… CONTINUE READING
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