Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition.

@article{Fu2008OverexpressionOE,
  title={Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition.},
  author={Hai Fu and Tetsuo Minamino and Osamu Tsukamoto and Tamaki Sawada and Mitsutoshi Asai and Hisakazu Kato and Yoshihiro Asano and Masahiro Fujita and Seiji Takashima and Masatsugu Hori and Masafumi Kitakaze},
  journal={Cardiovascular research},
  year={2008},
  volume={79 4},
  pages={
          600-10
        }
}
AIMS Proteasome inhibitors are a novel class of anticancer agents that induce tumour cell death via endoplasmic reticulum (ER) stress. Since ER stress is involved in the development of heart failure, we investigated the role of ER-initiated cardiomyocyte death by proteasome inhibition. METHODS AND RESULTS Rat neonatal cardiomyocytes were used in this study. Proteasome activity was assayed using proteasome peptidase substrates. Cell viability and apoptosis were measured by 3-(4,5… CONTINUE READING

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