Overexpression of eNOS prevents the development of renovascular hypertension in mice.

@article{Gava2008OverexpressionOE,
  title={Overexpression of eNOS prevents the development of renovascular hypertension in mice.},
  author={{\'A}. Gava and V. Peotta and A. M. Cabral and E. C. Vasquez and S. S. Meyrelles},
  journal={Canadian journal of physiology and pharmacology},
  year={2008},
  volume={86 7},
  pages={
          458-64
        }
}
Gene therapy has become an important tool for understanding several cardiovascular diseases. In the present study we investigated the effects of endothelial nitric oxide synthase (eNOS) overexpression on renovascular hypertension. Experiments were carried out in C57BL/6 mice randomly assigned to either a two-kidney one-clip (2K1C) hypertension group or a sham-operated group. At the same time surgery was carried out, both 2K1C and sham mice received an intravenous injection of recombinant… Expand
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Evaluation of autonomic control of HR showed an increased sympathetic tone and a tendency to a decreased vagal tone in 2K1C mice compared with that in sham mice, and the baroreflex sensitivity was greatly decreased. Expand
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