Overexpression of eNOS prevents the development of renovascular hypertension in mice.

@article{Gava2008OverexpressionOE,
  title={Overexpression of eNOS prevents the development of renovascular hypertension in mice.},
  author={{\'A}gata Lages Gava and Veronica A Peotta and Ant{\^o}nio M. Cabral and Elisardo Corral Vasquez and Silvana Santos Meyrelles},
  journal={Canadian journal of physiology and pharmacology},
  year={2008},
  volume={86 7},
  pages={
          458-64
        }
}
Gene therapy has become an important tool for understanding several cardiovascular diseases. In the present study we investigated the effects of endothelial nitric oxide synthase (eNOS) overexpression on renovascular hypertension. Experiments were carried out in C57BL/6 mice randomly assigned to either a two-kidney one-clip (2K1C) hypertension group or a sham-operated group. At the same time surgery was carried out, both 2K1C and sham mice received an intravenous injection of recombinant… 
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