Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.

@article{Jacobi2005OverexpressionOD,
  title={Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.},
  author={Johannes Jacobi and Karsten Sydow and Georges von Degenfeld and Ying Zhang and Hayan Dayoub and Bingyin Wang and Andrew J. Patterson and Masumi Kimoto and Helen M. Blau and John P Cooke},
  journal={Circulation},
  year={2005},
  volume={111 11},
  pages={1431-8}
}
BACKGROUND This study was designed to determine whether overexpression of the enzyme dimethylarginine dimethylaminohydrolase (DDAH) could enhance angiogenesis by reducing levels of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). METHODS AND RESULTS In DDAH1 transgenic (TG) and wild-type mice (each n=42), the role of DDAH overexpression on angiogenesis was studied by use of the disk angiogenesis system and a murine model of hindlimb ischemia (each n=21… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous methylarginines.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2016

Effect of asymmetric dimethylarginine (ADMA) on heart failure development.

Nitric oxide : biology and chemistry • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Factors regulating arteriogenesis.

Arteriosclerosis, thrombosis, and vascular biology • 2003

Similar Papers

Loading similar papers…