Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.

@article{Xiao2010OverexpressionOC,
  title={Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.},
  author={Bin Xiao and Xuguang Li and Jiangtao Yan and Xuefeng Yu and Guangtian Yang and Xiao Xiao and James W Voltz and Darryl C. Zeldin and Dao Wen Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={334 3},
  pages={784-94}
}
Cytochrome P450 (P450)-derived epoxyeicosatrienoic acids (EETs) exert well recognized vasodilatory, diuretic, and tubular fluid-electrolyte transport actions that are predictive of a hypotensive effect. The study sought to determine the improvement of hypertension and cardiac function by overexpressing P450 epoxygenases in vivo. Long-term expression of CYP102 F87V or CYP2J2 in spontaneously hypertensive rats (SHR) was mediated by using a type 8 recombinant adeno-associated virus (rAAV8) vector… CONTINUE READING

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