Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development.

@article{Lonardo1999OverexpressionOC,
  title={Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development.},
  author={Fulvio Lonardo and Valerie M Rusch and John Langenfeld and Ethan Dmitrovsky and David S. Klimstra},
  journal={Cancer research},
  year={1999},
  volume={59 10},
  pages={2470-6}
}
Increased protein expression of the G1 cyclins D1 and E is reported in invasive non-small cell lung carcinoma. However, during transformation of the bronchial epithelium, overexpression of these species occurs, and their relationship to aberrant expression of p53 and retinoblastoma (Rb) has not been described previously. To determine the expression of these cell cycle regulators during the development of invasive squamous cell carcinoma (SCC) of the lung, the immunohistochemical expression… CONTINUE READING