Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer.

Cyclin E is one of the key regulators of the G(1)/S transition in the cell cycle. Overexpression of cyclin E has been observed in several malignancies and is associated with high proliferation, aberrant expression of other cell cycle regulators and chromosomal instability in vitro. To explore potential associations between cyclin E deregulation and… CONTINUE READING