Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: Anin situ hybridization analysis

@article{Kristt2000OverexpressionOC,
  title={Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: Anin situ hybridization analysis},
  author={Don Kristt and Isaac Turner and Rumelia Koren and Edward Ramadan and Rivka Gal},
  journal={Pathology Oncology Research},
  year={2000},
  volume={6},
  pages={65-70}
}
Increased expression of a key cell cycle regulator, cyclin Dl, may have relevance to carcinogenesis and clinicopathological characteristics of some cancers. This study represents the first application ofin situ hybridization, ISH, to detect cyclin Dl mRNA in tissue sections from colorectal carcinomas. This approach was selected because of its unique potential to clarify whether increased expression of cyclin Dl mRNA correlates with clinical and pathological parameters. The ISH of a non… CONTINUE READING
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