Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

@article{Zhang2005OverexpressionOC,
  title={Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.},
  author={Xiaoboo Zhang and John P. Gaspard and Yusuke Mizukami and Jingnan Li and Fiona Graeme-Cook and Daniel C. Chung},
  journal={Diabetes},
  year={2005},
  volume={54 3},
  pages={712-9}
}
Cyclin D1 can stimulate proliferation by driving cells from the G1 into the S-phase of the mammalian cell cycle. Previous animal studies have implicated the G1-S transition as a key regulatory checkpoint governing the proliferation of pancreatic islet cells. We expressed cyclin D1 in the beta-cells of mice and islet hyperplasia developed in a time-dependent… CONTINUE READING