Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.

@article{Chuma2004OverexpressionOC,
  title={Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.},
  author={Makoto Chuma and Michiie Sakamoto and Jun Yasuda and Gen Fujii and Kazuaki Nakanishi and Akira Tsuchiya and Tsutomu Ohta and Masahiro Asaka and Setsuo Hirohashi},
  journal={Journal of hepatology},
  year={2004},
  volume={41 4},
  pages={629-36}
}
BACKGROUND/AIMS The molecular basis of the metastasis of hepatocellular carcinoma (HCC) is not fully understood. The aim of this study was to elucidate the crucial genes involved in metastasis of HCC. METHODS We compared expression profiles among highly metastatic HCC cell lines and non-metastatic HCC cell lines by using oligonucleotide array to identify genes associated with metastasis. We further investigated the effect of identified gene on cell motility and metastasis in vitro and in vivo… CONTINUE READING

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