Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production

@article{Selvaratnam2016OverexpressionOC,
  title={Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production},
  author={Johanna Selvaratnam and B. Robaire},
  journal={Experimental Gerontology},
  year={2016},
  volume={84},
  pages={12-20}
}
  • Johanna Selvaratnam, B. Robaire
  • Published 2016
  • Biology, Medicine
  • Experimental Gerontology
  • Advanced paternal age is associated with increased complications in pregnancy and genetic diseases in offspring. Oxidative stress is a major contributor to the damage accumulated in sperm during aging. Complex networks of antioxidants regulate reactive oxygen species (ROS) in the testis. While mounting evident shows that redox dysfunction compromises the quality of developing male germ cells, the mechanisms by which aging causes this remain unclear. Furthermore, therapies to successfully… CONTINUE READING
    15 Citations
    Redox regulation of fertility in aging male and the role of antioxidants: A savior or stressor.
    • 17
    • PDF
    DNA damage in human spermatozoa; important contributor to mutagenesis in the offspring
    • R. Aitken
    • Biology, Medicine
    • Translational andrology and urology
    • 2017
    • 22
    • PDF
    Extender Supplementation with Antioxidants Selected after the Evaluation of Sperm Susceptibility to Oxidative Challenges in Goats
    Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix
    • M. Brand
    • Chemistry, Medicine
    • Critical reviews in biochemistry and molecular biology
    • 2020
    • 1
    On the epigenetic role of guanosine oxidation
    • 9
    Differential proliferation and metabolic activity of Sertoli cells in the testes of broiler and layer breeder chickens
    • 6

    References

    SHOWING 1-10 OF 50 REFERENCES
    Relative impact of oxidative stress on male reproductive function.
    • S. Sikka
    • Biology, Medicine
    • Current medicinal chemistry
    • 2001
    • 529
    Male Rat Germ Cells Display Age-Dependent and Cell-Specific Susceptibility in Response to Oxidative Stress Challenges1
    • 13
    • PDF
    The Effects of Long-Term Vitamin E Treatment on Gene Expression and Oxidative Stress Damage in the Aging Brown Norway Rat Epididymis1
    • 22
    • PDF
    The Enzymatic Antioxidant System of Human Spermatozoa
    • 49
    • PDF
    Roles of Reactive Oxygen Species in the Spermatogenesis Regulation
    • 89
    • PDF
    Aging and the brown Norway rat leydig cell antioxidant defense system.
    • 104
    • PDF
    Antioxidant systems and oxidative stress in the testes
    • 580
    • Highly Influential
    • PDF
    Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
    • 259
    • PDF
    Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
    • 63
    • PDF