Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production

  title={Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production},
  author={Johanna Selvaratnam and B. Robaire},
  journal={Experimental Gerontology},
  • Johanna Selvaratnam, B. Robaire
  • Published 2016
  • Biology, Medicine
  • Experimental Gerontology
  • Advanced paternal age is associated with increased complications in pregnancy and genetic diseases in offspring. Oxidative stress is a major contributor to the damage accumulated in sperm during aging. Complex networks of antioxidants regulate reactive oxygen species (ROS) in the testis. While mounting evident shows that redox dysfunction compromises the quality of developing male germ cells, the mechanisms by which aging causes this remain unclear. Furthermore, therapies to successfully… CONTINUE READING
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