Overexpression of caspase-3 in hepatocellular carcinomas

  title={Overexpression of caspase-3 in hepatocellular carcinomas},
  author={Rajendra A Persad and Chen Liu and Tsung-Teh Wu and Patrick Scott Houlihan and Stanley R. Hamilton and Anna Mac Diehl and A Rashid},
  journal={Modern Pathology},
Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied. Therefore, we studied its expression in four hepatoma cell lines and 22 HCCs by Western blot, and correlated the findings with in vitro caspase-3 activity… CONTINUE READING
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