Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis

@article{Hijiya2017OverexpressionOC,
  title={Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis},
  author={Naoki Hijiya and Tomotaka Shibata and Tsutomu Daa and Ryoji Hamanaka and Tomohisa Uchida and Keiko Matsuura and Yoshiyuki Tsukamoto and Chisato Nakada and Hidekatsu Iha and Masafumi Inomata and Masatsugu Moriyama},
  journal={Pathology International},
  year={2017},
  volume={67}
}
In patients with esophageal squamous cell carcinoma (ESCC), the status of metastasis to lymph nodes is strongly associated with prognosis. Consequently, development of a biomarker to detect the presence of metastasis would be clinically valuable. In this study, we found that overexpression of cannabinoid receptor 1 (CB1R) was applicable as a marker for prediction of metastasis in ESCC. CB1R overexpression was detected immunohistochemically in 54 of 88 cases (61.4%). The intensity of CB1R… 
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