Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells

@article{Kondo2001OverexpressionOC,
  title={Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells},
  author={Masashi Kondo and Lin Qin Ji and Craig Kamibayashi and Yoshio Tomizawa and Dwight E Randle and Yoshitaka S Sekido and Jun Yokota and Vladimir Kashuba and Eugene R. Zabarovsky and Igor Kuzmin and Michael Lerman and Jack Roth and John D. Minna},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={6258-6262}
}
Recently we identified FUS1 as a candidate tumor suppressor gene (TSG) in the 120 kb 3p21.3 critical region contained in nested lung and breast cancer homozygous deletions. Mutation of FUS1 is infrequent in lung cancers which we have confirmed in 40 other primary lung cancers. In addition, we found no evidence for FUS1 promoter region methylation. Because haploinsufficiency or low expression of Fus1 may play a role in lung tumorigenesis, we tested the effect of exogenously induced… CONTINUE READING
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