Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol

@article{Yu1998OverexpressionOB,
  title={Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol},
  author={Dihua Yu and Bolin Liu and Tong Jing and Dantong Sun and Janet E. Price and Sonja E. Singletary and Nuhad Ibrahim and Gabriel N Hortobagyi and M -C Hung},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2087-2094}
}
We recently found that overexpression of p185c-erbB2 in c-erbB2 transfected MDA-MB-435 breast cancer cells (435.eB transfectants) confers a 5–9-fold increase in Taxol resistance. To examine whether Taxol resistance is a common phenomenon in other c-erbB2 overexpressing breast cancer cell lines, we tested a panel of human breast cancer cell lines established from different patients and expressing p185c-erbB2 at different levels for their sensitivity to Taxol and Taxotere, a synthetic taxoid… CONTINUE READING