Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

@article{Pippig1993OverexpressionOB,
  title={Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.},
  author={Susanne Pippig and S Andexinger and Kiefer Daniel and Mechthild Puzicha and Marc G. Caron and Robert J Lefkowitz and Martin J. Lohse},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 5},
  pages={3201-8}
}
Receptor-specific or homologous desensitization of beta 2-adrenergic receptors is thought to be effected via phosphorylation of the receptor by the beta-adrenergic receptor kinase (beta ARK), followed by binding of beta-arrestin. We have generated stably transfected Chinese hamster ovary cell lines overexpressing either of the two regulatory proteins and also expressing low or high levels of beta 2-adrenergic receptors (approximately 80 and approximately 600 fmol/mg of membrane protein). In… CONTINUE READING

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