Overexpression of aquaporin‑1 aggravates hippocampal damage in mouse traumatic brain injury models.

@article{Qiu2014OverexpressionOA,
  title={Overexpression of aquaporin‑1 aggravates hippocampal damage in mouse traumatic brain injury models.},
  author={Bo Qiu and Xinguo Li and Xiyang Sun and Yong Wang and Zhitao Jing and Xu Zhang and Yunjie Wang},
  journal={Molecular medicine reports},
  year={2014},
  volume={9 3},
  pages={
          916-22
        }
}
'Secondary insult' following primary traumatic brain injury (TBI), including ischemia and edema, may aggravate brain impairments and affect the outcomes. The hippocampus is particularly sensitive to ischemia or edema due to its selective vulnerability, as neural cells of the hippocampus may be more prone to abnormal function or cell death in response to ischemia and edema. Aquaporin‑1 (AQP‑1) was reported to be associated with cerebral edema; however, the expression and role of AQP‑1 in… CONTINUE READING

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