Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.

  title={Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.},
  author={Xing-Mei Zhang and Xi-jing Mao and Hong-Liang Zhang and Xiang-yu Zheng and Therese M Pham and Abdu Adem and Bengt Winblad and Eilhard Mix and Jie Zhu},
  journal={Experimental neurology},
  volume={233 1},
Apolipoprotein E (apoE) has an intricate biological function in modulating immune responses and apoE isoforms exhibit diverse effects on neurodegenerative and neuroinflammatory disorders. In the present study, we investigated the individual roles of apoE isoforms in the kainic acid (KA)-induced hippocampal neurodegeneration with focus on immune response and microglia functions. ApoE2, 3 and 4 transgenic mice as well as wild-type (WT) mice were treated with KA by intranasal route. ApoE4… CONTINUE READING


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TheMouse Brain in Stereotaxic Coordinates

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