Overexpression of agrin isoforms in Xenopus embryos alters the distribution of synaptic acetylcholine receptors during development of the neuromuscular junction.

@article{Godfrey1999OverexpressionOA,
  title={Overexpression of agrin isoforms in Xenopus embryos alters the distribution of synaptic acetylcholine receptors during development of the neuromuscular junction.},
  author={Earl W. Godfrey and J Roe and R. David Heathcote},
  journal={Developmental biology},
  year={1999},
  volume={205 1},
  pages={22-32}
}
Synapse formation involves a large number of macromolecules found in both presynaptic nerve terminals and postsynaptic cells. Many of the molecules involved in synaptogenesis of the neuromuscular junction have been discovered through morphological localization to the synapse and functional cell culture assays, but their role in embryonic development has been more difficult to study. One of the best understood of these molecules is agrin, a synaptic extracellular matrix protein secreted by both… CONTINUE READING

Similar Papers

Loading similar papers…