Overexpression of agouti protein and stress responsiveness in mice

@article{Harris2001OverexpressionOA,
  title={Overexpression of agouti protein and stress responsiveness in mice},
  author={Ruth Babette Harris and Jun Zhou and Mingxia Shi and Stephen M. Redmann and Donna H Ryan},
  journal={Physiology & Behavior},
  year={2001},
  volume={73},
  pages={599-608}
}
Ectopic overexpression of agouti protein, an endogenous antagonist of melanocortin receptors' linked to the beta-actin promoter (BAPa) in mice, produces a phenotype of yellow coat color, Type II diabetes, obesity and increased somatic growth. Spontaneous overexpression of agouti increases stress-induced weight loss. In these experiments, other aspects of stress responsiveness were tested in 12-week-old male wild-type mice and BAPa mice. Two hours of restraint on three consecutive days produced… CONTINUE READING
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