Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.

@article{Shen2014OverexpressionOA,
  title={Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.},
  author={Hai-ying Shen and Hai Feng Sun and Marissa M Hanthorn and Zhongwei Zhi and Jing-quan Lan and David J. Poulsen and Ruikang K. Wang and Detlev Boison},
  journal={Journal of neurosurgery},
  year={2014},
  volume={120 3},
  pages={628-38}
}
OBJECT New experimental models and diagnostic methods are needed to better understand the pathophysiology of focal neocortical epilepsies in a search for improved epilepsy treatment options. The authors hypothesized that a focal disruption of adenosine homeostasis in the neocortex might be sufficient to trigger electrographic seizures. They further… CONTINUE READING