Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.

@article{Parkes2006OverexpressionOA,
  title={Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.},
  author={Heidi A Parkes and Elaine Preston and Donna L Wilks and Mercedes Ballesteros and Lee Carpenter and Leonie R. Wood and Edward W. Kraegen and Stuart M Furler and Gregory James Cooney},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 4},
  pages={E737-44}
}
Accumulation of intracellular lipid in obesity is associated with metabolic disease in many tissues including liver. Storage of fatty acid as triglyceride (TG) requires the activation of fatty acids to long-chain acyl-CoAs (LC-CoA) by the enzyme acyl-CoA synthetase (ACSL). There are five known isoforms of ACSL (ACSL1, -3, -4, -5, -6), which vary in their tissue specificity and affinity for fatty acid substrates. To investigate the role of ACSL1 in the regulation of lipid metabolism, we used… CONTINUE READING
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