Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.

@article{Hsu2007OverexpressionOA,
  title={Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.},
  author={H C Hsu and Yalei Wu and Pingar Yang and Qi Hong Wu and Godwin Job and Jianchu Chen and John H. Wang and Mary Ann V. Accavitti-Loper and William E. Grizzle and Robert H. Carter and John D. Mountz},
  journal={Journal of immunology},
  year={2007},
  volume={178 8},
  pages={5357-65}
}
Defective receptor editing or defective B cell checkpoints have been associated with increased frequency of multireactive autoantibodies in autoimmune disease. However, Ig somatic hypermutation and/or class switch recombination may be mechanisms enabling the development of pathogenic multireactive autoantibodies. In this study, we report that, in the BXD2 mouse model of autoimmune disease, elevated expression of activation-induced cytidine deaminase (AID) in recirculating follicular CD86… CONTINUE READING

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