Overexpression of a potassium channel gene perturbs neural differentiation.

  title={Overexpression of a potassium channel gene perturbs neural differentiation.},
  author={Susan May Jones and Angeles B Ribera},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 5 Pt 1},
Functional regulation of potassium currents in developing neurons is pivotal for changes in excitability and action potential waveform. Here, we test whether an excess of potassium channel transcripts is sufficient to drive functional expression of potassium current and shortening of the duration of the action potential. Injection of Shaker-like potassium channel transcripts into two-cell stage embryos achieves increases in RNA levels. The elevated levels of potassium channel RNA produce larger… CONTINUE READING
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