Overexpression of a non-native deoxyxylulose-dependent vitamin B6 pathway in Bacillus subtilis for the production of pyridoxine.

@article{Commichau2014OverexpressionOA,
  title={Overexpression of a non-native deoxyxylulose-dependent vitamin B6 pathway in Bacillus subtilis for the production of pyridoxine.},
  author={Fabian M. Commichau and Ariane Alzinger and Rafael Sande and Werner Bretzel and Frederik M. Meyer and Bastien Chevreux and Markus Wyss and Hans-Peter Hohmann and Zolt{\'a}n Pr{\'a}gai},
  journal={Metabolic engineering},
  year={2014},
  volume={25},
  pages={
          38-49
        }
}
Vitamin B6 is a designation for the vitamers pyridoxine, pyridoxal, pyridoxamine, and their respective 5'-phosphates. Pyridoxal 5'-phosphate, the biologically most-important vitamer, serves as a cofactor for many enzymes, mainly active in amino acid metabolism. While microorganisms and plants are capable of synthesizing vitamin B6, other organisms have to ingest it. The vitamer pyridoxine, which is used as a dietary supplement for animals and humans is commercially produced by chemical… CONTINUE READING
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