Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice

@article{Li2007OverexpressionOA,
  title={Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice},
  author={C Li and Yan-yan Zhan and Wenshu Li and Chenjie Xu and Wen-Xie Xu and Danghui Yu and R-Y Peng and Yuanxiao Cui and X Yang and Ning Hou and Y-h Li and Bai-hua Dong and Hui B. Sun},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={2277-2286}
}
Erythroid differentiation-associated gene (EDAG) is a hematopoietic tissue-specific gene that is highly expressed in the earliest CD34+ lin− bone marrow (BM) cells and involved in the proliferation and differentiation of hematopoietic cells. To investigate the role of EDAG in hematopoiesis, we established an EDAG transgenic mouse model driven by human CD11a promoter. The transgenic mice showed increased mortality with severe organ infiltration by neutrophils, and the homeostasis of… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

[Expression of EDAG-1 gene in human leukemia and lymphoma cell lines].

Ai zheng = Aizheng = Chinese journal of cancer • 2004

Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists • 2003