Overexpression of a gene cluster encoding a chalcone synthase-like protein confers redbrown pigment production in Streptomyces griseus.

@article{Ueda1995OverexpressionOA,
  title={Overexpression of a gene cluster encoding a chalcone synthase-like protein confers redbrown pigment production in Streptomyces griseus.},
  author={Kouichi Ueda and Kyoung Mi Kim and Teruhiko Beppu and Sueharu Horinouchi},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 7},
  pages={638-46}
}
A 7.0-kb DNA fragment that conferred redbrown pigment production on Streptomyces griseus was shotgun-cloned with a multicopy vector pIJ486 from this microorganism. By restriction endonuclease mapping and subcloning, a 1.5-kb fragment which is essential for the production of redbrown pigment was determined. The nucleotide sequence of this region revealed the presence of two open reading frames, ORF1 with 109 amino acids (named RppA) and ORF2 with 262 amino acids (RppB), in addition to a… CONTINUE READING

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