Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype.

@article{McAllister2014OverexpressionOA,
  title={Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype.},
  author={J. M. McAllister and Bhavi Modi and Bruce A Miller and Jessica M. Biegler and Richard Bruggeman and Richard S Legro and Jerome F Strauss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 15},
  pages={E1519-27}
}
Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5-7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which encodes a protein associated with clathrin-coated pits where cell-surface receptors reside. However, these studies provided no information about functional roles for DENND1A in the pathogenesis of PCOS… CONTINUE READING
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