Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A

@article{Yuki2015OverexpressionOZ,
  title={Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A},
  author={Ryuzaburo Yuki and K. Aoyama and S. Kubota and N. Yamaguchi and Shoichi Kubota and H. Hasegawa and Mariko Morii and X. Huang and K. Liu and J. Williams and M. Fukuda},
  journal={Journal of Cellular Biochemistry},
  year={2015},
  volume={116}
}
  • Ryuzaburo Yuki, K. Aoyama, +9 authors N. Yamaguchi
  • Published 2015
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Krüppel‐associated box‐containing zinc finger proteins (KRAB‐ZFPs) regulate a wide range of cellular processes. KRAB‐ZFPs have a KRAB domain, which binds to transcriptional corepressors, and a zinc finger domain, which binds to DNA to activate or repress gene transcription. Here, we characterize ZNF777, a member of KRAB‐ZFPs. We show that ZNF777 localizes to the nucleus and inducible overexpression of ZNF777 inhibits cell proliferation in a manner dependent on its zinc finger domain but… CONTINUE READING
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