Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A

  title={Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A},
  author={Ryuzaburo Yuki and K. Aoyama and S. Kubota and N. Yamaguchi and Shoichi Kubota and H. Hasegawa and Mariko Morii and X. Huang and K. Liu and J. Williams and M. Fukuda},
  journal={Journal of Cellular Biochemistry},
  • Ryuzaburo Yuki, K. Aoyama, +9 authors N. Yamaguchi
  • Published 2015
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Krüppel‐associated box‐containing zinc finger proteins (KRAB‐ZFPs) regulate a wide range of cellular processes. KRAB‐ZFPs have a KRAB domain, which binds to transcriptional corepressors, and a zinc finger domain, which binds to DNA to activate or repress gene transcription. Here, we characterize ZNF777, a member of KRAB‐ZFPs. We show that ZNF777 localizes to the nucleus and inducible overexpression of ZNF777 inhibits cell proliferation in a manner dependent on its zinc finger domain but… CONTINUE READING
    13 Citations
    Zinc Finger Protein 521, Negatively Regulated by MicroRNA-204-5p, Promotes Proliferation, Motility and Invasion of Gastric Cancer Cells
    • 2
    • PDF
    Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530*
    • 12
    • PDF
    Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer
    • 13
    • PDF
    FAM129A promotes invasion and proliferation by activating FAK signaling pathway in non-small cell lung cancer.
    • 1
    • PDF
    miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A
    • 1


    Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression.
    • 28
    KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1.
    • 46
    • PDF
    KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions
    • 137
    • PDF
    Sequence-Specific Transcriptional Repression by KS1, a Multiple-Zinc-Finger–Krüppel-Associated Box Protein
    • 74
    • PDF
    ZNF224: Structure and role of a multifunctional KRAB-ZFP protein.
    • 18
    Clustered organization of homologous KRAB zinc‐finger genes with enhanced expression in human T lymphoid cells.
    • 120
    The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.
    • 333
    • PDF
    KRAB-containing zinc-finger repressor proteins
    • 429
    TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas
    • 19
    • PDF