Overexpression of X-linked genes in T cells from women with lupus.

  title={Overexpression of X-linked genes in T cells from women with lupus.},
  author={Anura Hewagama and Gabriela Gorelik and Dipak R. Patel and Punsisi Liyanarachchi and William J. Mccune and E C Somers and Tania C Gonz{\'a}lez-Rivera and Faith M. Strickland and Bruce C. Richardson},
  journal={Journal of autoimmunity},
Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY) develop lupus at approximately the same rate as women suggests that a second X chromosome contributes. However, since the second X is normally inactivated, how it predisposes to lupus is unclear. DNA methylation contributes to the silencing of one X chromosome in women, and CD4+ T cell DNA demethylation contributes to the development of lupus-like… CONTINUE READING
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