Overexpression of Wilms Tumor 1 Gene as a Negative Prognostic Indicator in Acute Myeloid Leukemia

@inproceedings{Lyu2014OverexpressionOW,
  title={Overexpression of Wilms Tumor 1 Gene as a Negative Prognostic Indicator in Acute Myeloid Leukemia},
  author={Xiaodong Lyu and Yaping Xin and Ruihua Mi and Jing Ding and Xianwei Wang and Jieying Hu and Ruihua Fan and Xudong Wei and Yongping Song and Richard Y Zhao},
  booktitle={PloS one},
  year={2014}
}
Chromosomal aberrations are useful in assessing treatment options and clinical outcomes of acute myeloid leukemia (AML) patients. However, 40 ∼ 50% of the AML patients showed no chromosomal abnormalities, i.e., with normal cytogenetics aka the CN-AML patients. Testing of molecular aberrations such as FLT3 or NPM1 can help to define clinical outcomes in the CN-AML patients but with various successes. Goal of this study was to test the possibility of Wilms' tumor 1 (WT1) gene overexpression as an… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2011
VIEW 1 EXCERPT

WT1 overexpression at diagnosis may predict favorable outcome in patients with de novo non-M3 acute myeloid leukemia.

Maurizio Miglino, Nicoletta Colombo, +16 authors Marco Gobbi
  • Leukemia & lymphoma
  • 2011
VIEW 1 EXCERPT